Add new comment

Warning message

All forms are disabled.

Experimental Studies of Anticipative Dynamics in Neuronal Networks

 

Abstract

Understanding how neural systems integrate sensory signals to perceive time is a fundamental problem. However, the basic neuronal mechanism of temporal perception is still far from clear. Currently, there is a debate on whether a specialized clock is needed for time perception (TP). Our view is that TP can be a general property of neural networks endowed with short term synaptic plasticity (STSP) and enough recurrent connections. Recent simulation studies of anticipative dynamics (one form of TP) support this later mechanism. The goals of our proposed experiments are: i) to demonstrate that STSP is crucial in the anticipative dynamics in the retina of frogs and ii) to induce anticipative dynamics in a cortical neuronal culture of rats by using a recently invented photo-sensitive technique based on the organic semi-conducting polymers, P3HT. Since there are no special clock circuits in the retina and the cortical culture, results our proposed works will help to clear some of the controversies in the perception of time. 

Reference

[1]  A. T. Winfree, The Geometry of Biological Time, Springer, (2001) 19.

[2] R.B. Ivry, J.E. Schlerf, Dedicated and intrinsic models of time perception, Trends Cogn Sci, 12 (2008) 273-280. 

[3]  G.Schwartz,R.Harris,D.Shrom,M.J.Berry,II,Detection and prediction of periodic patterns by the retina, Nat. Neurosci., 10 (2007) 552-554.

[4]  R.B. Ivry, R.M. Spencer, H.N. Zelaznik, J. Diedrichsen, The cerebellum and event timing, Ann N Y Acad Sci, 978 (2002) 302-317.

[5]  V. Jacob1, L. Petreanu, N. Wright1, K. Svoboda, K. Fox, Regular Spiking and Intrinsic Bursting Pyramidal Cells Show Orthogonal Forms of Experience-Dependent Plasticity in Layer V of Barrel Cortex, Neuron,

[6]  P.M. Lau, G.Q. Bi, Synaptic mechanisms of persistent reverberatory activity in neuronal networks, Proc. Natl. Acad. Sci. USA, 102 (2005) 10333-10338

[7]  V. Gautam, D. Rand, Y. Hanein, K.S. Narayan, A Polymer Optoelectronic Interface Provides Visual Cues to a Blind Retina, Adv. Material (2014) 26:1751-1756

[8] L. C. Jia, M. Sano, Pin-Yin Lai and C. K. Chan, ”Connectivity and Syhchronous Firing in Cortical Neuronal Networks ,Phys. Rev. Lett. (2004) 93, 088101 

[9] U.R. Karmarkar, D.V. Buonomano Timing in the absence of clocks: encoding time in neural network states. Neuron (2007) 53, 427–438 

Filtered HTML

  • Web page addresses and e-mail addresses turn into links automatically.
  • Allowed HTML tags: <a> <em> <strong> <cite> <blockquote> <code> <ul> <ol> <li> <dl> <dt> <dd>
  • Lines and paragraphs break automatically.
  • Mathematics inside the configured delimiters is rendered by MathJax. The default math delimiters are $$...$$ and \[...\] for displayed mathematics, and $...$ and \(...\) for in-line mathematics.

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Image CAPTCHA
Enter the characters shown in the image.